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Main Title Teratologic Evaluation of 2,3,4,6-Tetrachlorophenol (CAS No. 58-90-2) Administered to CD Rats on Gestational Days 6 through 15. Appendices 1 - 9.
Author George, J. D. ; Price, C. J. ;
CORP Author Dynamac Corp., Rockville, MD. ;Research Triangle Inst., Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Year Published 1987
Report Number EPA-68-01-7266; EPA/530/SW-88/017B;
Stock Number PB88-176169
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Dosage ; Tetrachlorophenol ; CAS 58-90-2 ; Teratogenesis
Library Call Number Additional Info Location Last
NTIS  PB88-176169 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 230p
Abstract The study examines the toxic and teratogenic effects of purified 2,3,4,6-tetrachlorophenol (TCP) administered by gavage to timed-pregnant CD rats during the period of major organogenesis, i.e., gestational days (gd) 6 through 15. The study is designed to examine the potential effects of the test compound upon maternal status, as well as the growth, viability and morphological development of the fetus. The test species, doses for the teratology study (0, 25, 100 and 200 mg/kg/day), route of administration, vehicle and dose volume have been selected by the sponsor based upon pre-existing toxicity data obtained from the available scientific literature and other unpublished studies recently conducted by the sponsor. The high dose selected for the teratology investigation is expected to produce significant evidence of maternal and/or fetal toxicity while allowing survival of at least 90% of treated females through scheduled sacrifice (gd 20).
Supplementary Notes See also PB88-176151. Portions of this document are not fully legible. Prepared in cooperation with Research Triangle Inst., Research Triangle Park, NC. Sponsored by Environmental Protection Agency, Washington, DC. Office of Solid Waste.
PUB Date Free Form 21 Aug 87
Category Codes 57Y#; 57E; 68G#
NTIS Prices PC A11/MF A01
Primary Description 200/01
Document Type NT
Cataloging Source NTIS/MT
Control Number 811328176
Origin NTIS
Type CAT