| Main Title |
Production of Low Molecular Weight Cadmium-Binding Proteins in Rabbit Lung Following Exposure to Cadmium Chloride. |
| Author |
Post, C. T. ;
Squibb, K. S. ;
Fowler, B. A. ;
Gardner, D. E. ;
Illing, J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Linkoeping Univ. (Sweden). |
| Year Published |
1982 |
| Report Number |
EPA/600/J-82/460; |
| Stock Number |
PB86-199460 |
| Additional Subjects |
Cadmium chloride ;
Proteins ;
Rabbits ;
Lung ;
Exposure ;
Binding ;
Pharmacology ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-199460 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Low molecular weight cadmium-binding proteins were studied in lung tissue from rabbits exposed to aerosols of CdCl2. Lungs obtained from animals exposed by inhalation to aerosols of 800 or 1600 micrograms/cu.m. CdCl2 for 2-hr periods/day, every other day for a 5-day period, were found to contain at least three low molecular weight cadmium-binding proteins, two of which were similar electrophoretically and spectrally to rabbit liver metallothionein. The third protein(s), which accounted for the majority of the cadmium in the soluble fraction of the tissue, did not bind to an anionic exchange gel and did not appear to be a polymerized form of metallothionein. Translocation studies of lung cadmium suggest a long half-life for cadmium in lung tissue following inhalation exposure, due perhaps to the high affinity of cadmium for specific lung cadmium-binding proteins. A small but significant redistribution of lung cadmium did occur to both kidney and liver tissue with time. |
| Supplementary Notes |
Pub. in Biochemical Pharmacology, v31 n18 p2969-2975 1982. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, NC., and Linkoeping Univ. (Sweden). |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Production of Low Molecular Weight Cadmium-Binding Proteins in Rabbit Lung Following Exposure to Cadmium Chloride. |
| PUB Date Free Form |
c1982 |
| Category Codes |
6O; 57Q |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
619921174 |
| Origin |
NTIS |
| Type |
CAT |
