| Main Title |
Role of Neurotoxic Esterase (NTE) in the Prevention and Potentiation of Organophosphorus-Induced Delayed Neurotoxicity (OPIDN). |
| Author |
Pope, C. N. ;
Tanaka, D. ;
Padilla, S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northeast Louisiana Univ., Monroe. School of Pharmacy. ;Michigan State Univ., East Lansing. Dept. of Anatomy. |
| Publisher |
1993 |
| Year Published |
1993 |
| Report Number |
EPA/600/J-94/032; |
| Stock Number |
PB94-137221 |
| Additional Subjects |
Esterases ;
Phosphorus organic compounds ;
Nervous system ;
Toxicity ;
Drug interactions ;
Enzyme inhibitors ;
Phosphorylation ;
Phenylmethylsulfonyl fluoride ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-137221 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
The first step in the initiation of organophosphorus-induced delayed neuropathy (OPIDN) is proposed to be the phosphorylation of an enzyme found in the nervous system called neurotoxic esterase (neuropathy target esterase, NTE). It has been known for over twenty years that non-neuropathic inhibitors of NTE exist and can actually prevent OPIDN when given before a neuropathic organophosphate (OP). Within the last three years it has become evident that another outcome is possible following in vivo interaction between neuropathic and nonneuropathic NTE inhibitors. When administered after OP exposure, nonneuropathic inhibitors can intensify or potentiate signs of OPIDN in adult chickens. Additionally, whereas developing chickens are typically resistant to the effects of neuropathic OPs, resistant age groups will develop OPIDN when exposure to a neuropathic OP is followed by the non-neuropathic NTE inhibitor phenylmethylsulfonyl fluoride. As in the case of prevention, studies of the potentiation of OPIDN may yield insight into mechanisms involved in the pathogenesis of delayed neurotoxicity. A brief review of current knowledge regarding the role of NTE in both the prevention and potentiation of OPIDN is presented. |
| Supplementary Notes |
Pub. in Chemico-Biological Interactions, v87 n1-3 p395-406 Jun 93. Prepared in cooperation with Northeast Louisiana Univ., Monroe. School of Pharmacy, and Michigan State Univ., East Lansing. Dept. of Anatomy. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Role of Neurotoxic Esterase (NTE) in the Prevention and Potentiation of Organophosphorus-Induced Delayed Neurotoxicity (OPIDN). |
| Category Codes |
57F; 57Y; 57B |
| NTIS Prices |
PC A03/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
407720024 |
| Origin |
NTIS |
| Type |
CAT |
