| Main Title |
Synaptonemal Complex Damage as a Measure of Genotoxicity at Meiosis. |
| Author |
Allen, J. W. ;
Poorman, P. A. ;
Backer, L. C. ;
Gibson, J. B. ;
Westbrook-Collins, B. ;
|
| CORP Author |
Burroughs Wellcome Co., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1988 |
| Report Number |
EPA-R-812736; EPA/600/D-88/136; |
| Stock Number |
PB88-223789 |
| Additional Subjects |
Toxicity ;
Genes ;
Meiosis ;
Cell division ;
Chromosomes ;
Mitomycins ;
Cyclophosphamide ;
Colchicine ;
Vinblastine ;
Laboratory animals ;
Mice ;
Chromosomal aberrations ;
Genetic disorders ;
Genotoxicity ;
Duplication(Genes) ;
Amsacrine ;
Ellipticines ;
Cisplatin ;
Chromosome damage ;
Synaptonemal complex
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-223789 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis-platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairing/synapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders. |
| Supplementary Notes |
Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and Duke Univ. Medical Center, Durham, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| PUB Date Free Form |
Jun 88 |
| Category Codes |
57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
826017170 |
| Origin |
NTIS |
| Type |
CAT |
