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OLS Field Name OLS Field Data
Main Title Time-Dependent Neurobiological Effects of Colchicine Administered Directly into the Hippocampus of Rats (Journal Version).
Author Tilson, H. A. ; Rogers, B. C. ; Grimes, L. ; Harry, G. J. ; Peterson, N. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/419;
Stock Number PB89-105944
Additional Subjects Neurobiology ; Colchicine ; Hippocampus ; Animal behavior ; Avoidance learning ; Pathology ; Dynorphin ; Methionine enkephalin ; Alkaloids ; Motor activity ; Startle reaction ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
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Checkout
Status
NTIS  PB89-105944 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 11p
Abstract Rats were given bilateral injections of colchicine into the dorsal and ventral hippocampus. Behavioral, neurochemical and histopathological measurements were taken up to 12 weeks after surgery. Colchicine produced a consistent increase in spontaneous motor activity, enhanced acoustic startle reactivity, and accelerated acquisition of two-way shuttle box avoidance, but did not affect reactivity to a noxious thermal stimulus. Measurement of dynorphin in the hippocampus indicated that colchicine rapidly depleted this neuropeptide, which is thought to be contained preferentially in the mossy fibers of granule cells of the hippocampus. Colchicine also decreased metenkephalin in the hippocampus, but the magnitude of the change (22%) was less than that (89% depletion) observed for hippocampal dynorphin. Examination of hippocampal morphology using light microscopic techniques indicated that colchicine caused approximately 60% degeneration of granule cells in the hippocampus. (Copyright (c) 1987 Elsevier Science Publishers B.V.)
Supplementary Notes Pub. in Brain Research, v408 p163-172 1987. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, NC., and North Carolina Univ. at Chapel Hill.
NTIS Title Notes Journal article.
Title Annotations Reprint: Time-Dependent Neurobiological Effects of Colchicine Administered Directly into the Hippocampus of Rats (Journal Version).
Category Codes 57S; 57O; 57Z
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 833027600
Origin NTIS
Type CAT