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Main Title Experimental Respiratory Carcinogenesis in Small Laboratory Animals.
Author Pepelko, W. E. ;
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.
Year Published 1984
Report Number EPA-600/J-84-026;
Stock Number PB84-201961
Additional Subjects Laboratory animals ; Toxicology ; Inhalation ; Exposure ; Lung diseases ; Reprints ; Carcinogenesis ; Air pollution effects(Animals) ; Cancer
Library Call Number Additional Info Location Last
NTIS  PB84-201961 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 46p
Abstract Studies designed to test the ability of environmental pollutants to induce lung cancer in experimental animals by chronic inhalation exposure are summarized in this review. The studies are limited to those published in peer-reviewed journals and may not include all experiments conducted by chemical or pharmaceutical manufacturers to test product safety. These studies are also limited to those using small laboratory animals, e.g., Syrian Golden hamsters, mice and rats. The advantages and disadvantages of these species for use in respiratory carcinogenesis studies are discussed. Chemical substances reviewed include organic compounds, inorganic metallic and nonmetallic compounds, and complex mixtures. The results of these studies have shown that cancer of the respiratory tract can be induced by a wide variety of chemicals, many of which are present in ambient air. With few exceptions, substances that have been shown to induce lung cancer in humans have also proven to be carcinogenic in laboratory animals.
Supplementary Notes Pub. in Environmental Research, 33 p144-188 1984.
NTIS Title Notes Journal article (Final).
Title Annotations Reprint: Experimental Respiratory Carcinogenesis in Small Laboratory Animals.
PUB Date Free Form 1984
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices PC A03/MF A01
Primary Description 600/22
Document Type NT
Cataloging Source NTIS/MT
Control Number 425821710
Origin NTIS
Type CAT