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Main Title Synthesis and Identification of Highly Toxic Polybrominated Biphenyls in the Fire Retardant FireMaster BP-6.
Author Robertson, L. W. ; Safe, S. H. ; Parkinson, A. ; Pellizzari, E. ; Pochini, C. ;
CORP Author Environmental Research Lab.-Duluth, Grosse Ile, MI. Large Lakes Research Station. ;Texas A and M Univ., College Station. ;ROCOM, Montclair, NJ. ;Research Triangle Inst., Research Triangle Park, NC.
Publisher c1984
Year Published 1984
Report Number EPA/600/J-84-426;
Stock Number PB90-106238
Additional Subjects Fire resistant materials ; Toxicity ; Mass spectroscopy ; Synthesis(Chemistry) ; Reprints ; Polybrominated biphenyls ; Gas chromatography
Library Call Number Additional Info Location Last
NTIS  PB90-106238 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract The accidental substitution of fireMaster, a commercial polybrominated biphenyl (PBB) flame retardant, for nutriMaster, a magnesium oxide cattle feed supplement, resulted in a major pollution disaster that was primarily confined to the State of Michigan. The initial contamination of cattle and related agricultural products ultimately resulted in the widespread contamination of the food chain within the state. The identity of over 91% of the polybrominated biphenyl (PBB) components present in fireMaster BP-6 was determined by capillary gas chromatography (GC) and GC-mass spectrometry (MS) with 22 individual PBB congeners as reference standards. There was an excellent correlation between the observed retention times of the individual PBBs (and of the corresponding GC peaks in fireMaster) and the expected retention times calculated from the degree of bromination and substituent orientation for the PBB standards. Previous studies indicate that the more toxic PBBs are also inducers of rat hepatic microsomal aryl hydrocarbon hydroxylas (AHH). The paper reports that GC and HV-MS identification of seven additional PBBs in fireMaster that also induce aryl hydrocarbon hydroxylas. Included in the group of seven potentially toxic PBBs are the coplanar 3,3', 4',4'-tetra-,3,3-,3,3-,5-penta-, and 3,3-,4,4-,5,5'-hexabromobiphenyls, which represent the most toxic group of PBB congeners identified in fireMaster. (Copyright (c) 1984 American Chemical Society.)
Supplementary Notes Pub. in Jnl. of Agricultural and Food Chemistry, v32, p1107-1111, 1984. Prepared in cooperation with Texas A and M Univ., College Station, ROCOM, Montclair, NJ., and Research Triangle Inst., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Synthesis and Identification of Highly Toxic Polybrominated Biphenyls in the Fire Retardant FireMaster BP-6.
Category Codes 57Y; 57B
NTIS Prices PC A02/MF A01
Primary Description 600/03
Document Type NT
Cataloging Source NTIS/MT
Control Number 932619187
Origin NTIS
Type CAT