Main Title |
Relationship of Neuropathy Target Esterase Inhibition to Neuropathology and Ataxia in Hens Given Organophosphorus Esters. |
Author |
Ehrich, M. ;
Jortner, B. S. ;
Padilla, S. ;
|
CORP Author |
Virginia-Maryland Regional Coll. of Veterinary Medicine, Blacksburg, VA.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
Publisher |
1993 |
Year Published |
1993 |
Report Number |
EPA-68-D8-0098; EPA/600/J-94/030; |
Stock Number |
PB94-137247 |
Additional Subjects |
Esterases ;
Enzyme inhibitors ;
Toxicology ;
Central nervous system ;
Phosphorous organic compounds ;
Ataxia ;
Esters ;
Pathology ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-137247 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Adult White Leghorn hens were acutely exposed to 3 dosages of the following organophosphorus compounds: mipafox, tri-ortho-tolyl phosphate (TOTP), phenyl saligenin phosphate, and diisopropylphosphorofluoridate (DFP). Neuropathy target esterase (NTE) activity was measured in brain and spinal cord 4 or 48 h after exposure. Ataxia was assessed using an 8-point rating scale on days 9 through 21 after administration, and neuropathological examination was conducted on samples collected from perfusion-fixed animals on day 21. Morphological alterations were indicated by lesion scores between 0 (no lesions) and 4 (diffuse involvement of spinal cord tracts and > 25% degeneration of peripheral nerve fibers). Dosages of mipafox, TOTP, phenyl saligenin phosphate, and DFP that were capable of inhibiting NTE > 80% in both brain and spinal cord preceded ataxia which reached maximal levels (scores of 7-8), and development of lesions scored as 4. Hens were notably impaired (ataxia scores of 3-4) 21 days after administration of dosages of mipafox, TOTP, phenyl saligenin phosphate, and DFP when spinal cord NTE was inhibited 40-75%. Lesions were, however, only noted in spinal cord and peripheral nerves of hens given TOTP or DFP (scores 1-3). |
Supplementary Notes |
Pub. in Chemico-Biological Interactions, v87 n1-3 p431-437 Jun 93. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Relationship of Neuropathy Target Esterase Inhibition to Neuropathology and Ataxia in Hens Given Organophosphorus Esters. |
Category Codes |
57Y; 57F; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
407720033 |
Origin |
NTIS |
Type |
CAT |