Main Title |
Phenylmethylsulfonyl Fluoride Protects Rats from Mipafox-Induced Delayed Neuropathy. |
Author |
Veronesi, B. ;
Padilla, S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/281; |
Stock Number |
PB86-157971 |
Additional Subjects |
Fluorides ;
Toxicology ;
Rats ;
Laboratory animals ;
Reprints ;
Neuropathy
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-157971 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Initiation of organophosphorus-induced delayed neuropathy (OPIDN) is thought to consist of two molecular events involving the phosphorylation of the target enzyme, neurotoxic esterase or neuropathy target enzyme (NTE), and a subsequent 'aging' reaction which transforms the inhibited NTE into a charged moiety critical to the neuropathic process. Compounds that inhibit NTE but cannot age because of their chemical structure abort this two-stage initiation process, and when administered before a neurotoxic organophosphorus compound (OP), protect against the neuropathy by blocking NTE's active site (Johnson, 1970). In support of this, the authors report that prior exposure to a non-aging NTE inhibitor, phenylmethylsulfonyl fluoride (PMSF), protects rats from neurological damage after subsequent exposure to a neurotoxic OP, Mipafox. Adult, male Long Evans rats were exposed to either PMSF (250mg/kg, sc) or to Mipafox (15 mg/kg, ip) and a time-course of brain NTE inhibition and recovery was defined. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 81, p258-264 Nov 85. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Phenylmethylsulfonyl Fluoride Protects Rats from Mipafox-Induced Delayed Neuropathy. |
PUB Date Free Form |
1985 |
Category Codes |
6T; 6O; 57Y; 57Q |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
611414004 |
Origin |
NTIS |
Type |
CAT |