Main Title |
Synthesis of a Novel Fluorinated Benzo(a)pyrene: 4,5-Difluorobenzo(a)pyrene. |
Author |
Agarwal, S. C. ;
Lambert, G. ;
Padgett, W. ;
Nesnow, S. ;
|
CORP Author |
Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA-68-02-4456; EPA/600/J-91/246; |
Stock Number |
PB92-110493 |
Additional Subjects |
Chemical reactions ;
Fluorescent dyes ;
Biochemistry ;
Benzo(a)pyrene ;
Metabolic activation ;
DNA damage ;
Carcinogens ;
Reprints ;
Benzo(a)pyrene/difluoro
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-110493 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
The synthesis of 4,5-difluorobenzo(a)pyrene, as a fluorinated probe to investigate the involvement of the K-region in the further metabolic activation of benzo(a)pyrene metabolites, is described. Benzo(a)pyrene-4,5-dione obtained from 2,3-dichloro-5,6-dicyano-1,4-benzoquinone oxidation of cis-4,5-dihydro-4,5-dihydroxybenzo(a)pyrene was fluorinated with dimethylaminosulfur trifluoride to give 4H,5H,4,4,5,5-tetrafluoro-benzo(a)pyrene. Defluorination using lithium aluminum hydride in tetrahydrofuran gave 4,5-difluorobenzo(a)pyrene. |
Supplementary Notes |
Pub. in Carcinogenesis, v12 n9 p1647-1650 Sep 91. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Synthesis of a Novel Fluorinated Benzo(a)pyrene: 4,5-Difluorobenzo(a)pyrene. |
Category Codes |
57B; 57Y; 99D |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
133921345 |
Origin |
NTIS |
Type |
CAT |