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OLS Field Name OLS Field Data
Main Title Neurotoxic effects of controlled exposure to a complex mixture of volatile organic compounds /
Author Otto, David A. ; Molhave, L. ; Hudnell, H. K. ; Goldstein, G. ; O'Neil, J.
Other Authors
Author Title of a Work
Otto, David A.,
M²lhave, Lars,
Hudnell, H. Kenneth,
Goldstein, George M.,
John O'Neil,
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Aarhus Univ. (Denmark). ;Northrop Services, Inc., Research Triangle Park, NC. ;CE Environmental, Inc., Chapel Hill, NC.
Publisher Health Effects Laboratory,
Year Published 1990
Report Number EPA/600/1-90/001
Stock Number PB90-186438
OCLC Number 224814869
Subjects Neurotoxicology. ; Organic compounds. ; Volatile organic compounds.
Additional Subjects Toxicology ; Exposure ; Eye(Anatomy) ; Nose(Anatomy) ; Pharynx ; Sensitivity ; Buildings ; Graphs(Charts) ; Tables(Data) ; Volatile organic compounds ; Biological effects ; Indoor air pollution
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-90-001 Headquarters Library/Washington,DC 05/06/2014
NTIS  PB90-186438 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 07/22/2019
Collation v, 98 pages ; 28 cm.
Abstract Subjective reactions of discomfort, impaired air quality, irritation of mucosal membranes, and impaired memory have been reported in chemically sensitive subjects during exposure to volatile organic compounds (VOCs) found in new buildings. 66 normal healthy male subjects aged 18-39 were exposed for 2.75 hrs to a complex VOC mixture at O and 25 mg/cu m. Each subject completed control and exposure sessions at one week intervals in counterbalanced order. Measurements included comfort ratings of eye, nose and throat irritation, symptom questionnaire and computerized behavioral tests. Subjects found the odor of VOCs unpleasant and strong and reported that VOC exposure degraded air quality, increased headache and produced general discomfort. VOC exposure did not affect performance on any behavioral tests. Results indicate that subjective reactions to VOCs are not limited to chemically sensitive individuals since the study population is a subgroup that is probably least likely to be affected by chemical exposure.
Notes Contract Number: EPA Contract 68-02-4179 Contract Number: EPA Contract 68-20-3800 Reproduction by U.S. Dept. of Commerce, National Technical Information Service, Springfield, VA.
Place Published Research Triangle Park, NC
Supplementary Notes Prepared in cooperation with Aarhus Univ. (Denmark), Northrop Services, Inc., Research Triangle Park, NC., and CE Environmental, Inc., Chapel Hill, NC.
Corporate Au Added Ent Center for Environmental Research Information (U.S.),; United States. National Technical Information Service.
PUB Date Free Form 1990
Series Title Untraced EPA (United States. Environmental Protection Agency) ; 600/1-90/001\ PB (United States. National Technical Information Service) ; 90-186438
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source RDA
OCLC Time Stamp 20150423115638
Language eng
Origin OCLC
OCLC Rec Leader 01943cam 2200457Ki 45020