Main Title |
Binding of Polychlorinated Biphenyls Classified as Either Phenobarbitone-, 3-Methylcholanthrene- or Mixed-Type Inducers to Cytosolic Ah Receptor. |
Author |
Bandiera, A. ;
Safe, S. ;
Okey, A. B. ;
|
CORP Author |
Guelph Univ. (Ontario). Guelph-Waterloo Centre.;Environmental Research Lab.-Duluth, MN. |
Year Published |
1982 |
Report Number |
EPA-R-809764; EPA-600/J-82-369; |
Stock Number |
PB83-240788 |
Additional Subjects |
Enzymes ;
Proteins ;
Chemical bonds ;
Binding ;
Laboratory animals ;
Environmental surveys ;
Toxicity ;
In vitro analysis ;
Chlorine organic compounds ;
Liver ;
Rats ;
Public health ;
Reprints ;
Polychlorinated biphenyls ;
Toxic substances ;
Cholanthrene/methyl,Phenobarbitone
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB83-240788 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
23p |
Abstract |
It has been postulated that reversible, high-affinity binding of 3-methyl-cholanthrene (MC)-type inducers to a receptor protein (the Ah receptor) in hepatic cytosol is essential for induction of aryl hydrocarbon hydroxylase (AHH) enzymic activity. To test this postulate, the binding affinities of 16 highly purified, synthetic chlorinated biphenyl (PCB) congeners, which have been categorized either as phenobarbitone (PB)-, MC- or mixed (PB + MC)-type inducers of cytochrome P-450-dependent monooxygenases have been examined. The affinity of individual biphenyl congeners for the receptor was determined by their competition with 2,3,7,8-(3 sup H) tetrachlorodibenzo-p-dioxin ((3 sup H)TCDD) for specific cytosolic binding sites as measured by sucrose density gradient analysis following dextran-charcoal treatment. |
Availability Notes |
Pub. in Chemico-Biological Interactions 39, p259-277 1982. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Binding of Polychlorinated Biphenyls Classified as Either Phenobarbitone-, 3-Methylcholanthrene- or Mixed-Type Inducers to Cytosolic Ah Receptor. |
PUB Date Free Form |
c1982 |
Category Codes |
7D; 6T; 6E; 68G; 57Y; 99F |
NTIS Prices |
Not available NTIS |
Primary Description |
600/03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
332920200 |
Origin |
NTIS |
Type |
CAT |