Main Title |
Inhibition of Microsomal Metabolism and Chemical Oncogenesis in Culture by Naphthalene Quinones. |
Author |
Nesnow, Stephen ;
Bergman, Hinda ;
Garland, Helen ;
Morris, Mary ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1980 |
Report Number |
EPA-600/J-79-149; |
Stock Number |
PB83-145284 |
Additional Subjects |
Ribosomes ;
Inhibition ;
Metabolism ;
Liver ;
Rats ;
Reprints ;
Oncogenesis ;
Naphthalene quinones
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB83-145284 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
16p |
Abstract |
A series of napthalene diols, quinones, and related compounds were examined for their ability to inhibit mixed-function oxidase activities in liver microsomes obtained from rats which had been pretreated with 3-methylcholanthrene (3-MC) or phenobarbital (PB). Using benzo(a)pyrene monooxygenase as a measure of mixed-function oxidase activity, it was found that phenanthrene-9,10-quinone was the most active compound tested with a K1=0.79 uM. |
Supplementary Notes |
Pub. in Jnl. of Environmental Pathology and Toxicology 4, p17-30 1980. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Inhibition of Microsomal Metabolism and Chemical Oncogenesis in Culture by Naphthalene Quinones. |
PUB Date Free Form |
18 Jun 80 |
Category Codes |
6T; 6E; 57Y; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
305048119 |
Origin |
NTIS |
Type |
CAT |