| Main Title |
Identification of Cocarcinogens and Their Potential Mechanisms of Action Using C3H10T(1/2)CL8 Mouse Embryo Fibroblasts. |
| Author |
Nesnow, Stephen ;
Leavitt, Sharon ;
Garland, Helen ;
Vaughan, T. Owens ;
Hyatt, Betty ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1981 |
| Report Number |
EPA-600/J-80-202; |
| Stock Number |
PB82-247206 |
| Additional Subjects |
Carcinogens ;
Toxicology ;
Identifying ;
Mice ;
Reprints ;
Fibroblasts ;
Fetuses
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-247206 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The cocarcinogenic action of five agents which increase microsomal mixed-function oxidase activity in vivo was examined in the C3H101/2CL8 transformation assay. The compounds studies were benz(a)anthracene, 5,6-benzoflavone, phenobarbital, pregnenolone-16a-carbon-nitrile, and Aroclor 1254. After a 48-hr pretreatment with the agent, the cells were then treated with benzo(a)pyrene (B(a)P) and the agent for an additional 24hr. This suggests that these agents exert their cocarcinogenic action via increases in the enzyme-mediated pathways of B(a)P metabolism. |
| Supplementary Notes |
Pub. in Cancer Research 41, p3071-3076 Aug 81. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Identification of Cocarcinogens and Their Potential Mechanisms of Action Using C3H10T(1/2)CL8 Mouse Embryo Fibroblasts. |
| PUB Date Free Form |
7 May 81 |
| Category Codes |
6T; 6C; 57Y; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323821753 |
| Origin |
NTIS |
| Type |
CAT |
