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Main Title Health assessment document for acrylonitrile /
Author Neal, Michael W. ; Basu, Dipak K. ; Sugatt, Richard H. ; Hsu, Robert S. ; Santodonato, Joseph
Other Authors
Author Title of a Work
Neal, M. W.
CORP Author United States. Environmental Protection Agency. Office of Research and Development.; Syracuse Univ. Research Corp., NY.; Environmental Protection Agency, Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development,
Year Published 1982
Report Number EPA-600-8-82-007; SRC-TR-81-596; EPA-68-02-3277; PB83129593
Stock Number PB83-129593
OCLC Number 10190184
Subjects Environmental health ; Acrylonitrile--Toxicology ; Carcinogens
Additional Subjects Environmental health ; Acrylonitrile--Toxicology ; Carcinogens ; Acrylonitriles ; Physical properties ; Chemical properties ; Sampling ; Sources ; Residues ; Transport ; Distribution ; Exposure ; Concentration(Composition) ; Humans ; Laboratory animals ; Air quality ; Analytical methods ; Biological effects ; Toxic substances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  EPA-600-8-82-007 Region 1 Library/Boston,MA 05/25/2016
EKBD  EPA-600/8-82-007 Research Triangle Park Library/RTP, NC 03/19/2004
ESAD  EPA 600-8-82-007 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB83-129593 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) ; 28 cm
Abstract Acrylonitrile is readily absorbed in animals following ingestion or inhalation, while dermal absorption is poor (1%) compared to that of the lungs. Acrylonitrile is metabolized to cyanide, which is transformed to thiocyanic acid and by cyanoethylation of sulfhydryl groups to S-(2 cyanoethyl) cysteine, followed by elimination of these metabolites in the urine. Symptoms of intoxication in humans include eye and nose irritation, weakness, labored breathing, dizziness, impaired judgement, cyanosis, nausea and convulsions. Similar symptoms have been observed in animals, including death. In experimental animals, there is considerable species variation in susceptibility to acrylonitrile intoxication; the guinea pig is the most resistant and the dog the most sensitive. Many of the pathological changes observed in rats under chronic exposure conditions are believed to be treatment related.
Notes "Draft. Do not cite or quote." "EPA-600/8-82-007." "November 1982." Includes bibliographical references.
Place Published Research Triangle Park, N.C.
Access Notes Also available via the World Wide Web.
Corporate Au Added Ent United States. Environmental Protection Agency. Office of Research and Development.
PUB Date Free Form 1982
NTIS Prices PC A14/MF A01
BIB Level m
Document Type BC
Medium unmediated
Content text
Carrier volume
Cataloging Source OCLC/T
Merged OCLC records 1032390720
OCLC Time Stamp 20160419144041
Language eng
Origin OCLC
OCLC Rec Leader 01653cam 2200385Ia 45020