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OLS Field Name OLS Field Data
Main Title Effects of Oral Exposure to Trichloroethylene on Female Reproductive Function.
Author Manson, J. M. ; Murphy, M. ; Richdale, N. ; Smith, M. K. ;
CORP Author Cincinnati Univ., OH. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/162;
Stock Number PB85-146769
Additional Subjects Toxicology ; Reproduction system ; Exposure ; Females ; Distribution ; Metabolism ; Ingestion(Biology) ; Rats ; Bioassay ; Laboratory animals ; Reprints ; Ethylene/trichloro
Library Call Number Additional Info Location Last
NTIS  PB85-146769 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 16p
Abstract In the present study, the distribution, metabolism and reproductive toxicity of trichloroethylene (TCE) administered by the oral route to female rats were examined. The distribution study with 14C-TCE indicated that relatively high levels of radioactivity accumulated in the ovary, adrenal gland and uterus of both pregnant and nonpregnant female rats, while embryonic tissue did not appear to preferentially accumulate radioactivity relative to other maternal organs or maternal blood. GC analysis of tissues from adult females after 3 weeks of exposure indicated that TCE levels were uniformly high in the fat, adrenal gland and ovary, that the metabolite, trichloroethanol (TCOH) did not accumulate to any appreciable extent in reproductive or steroidhormone producing organs, while trichloroacetic acid (TCA) levels were high in the uterus relative to other organs known to be major sites of biotransformation.
Availability Notes Pub. in Toxicology 32, p229-242 Sep 84.
NTIS Title Notes Journal artlcle.
Title Annotations Reprint: Effects of Oral Exposure to Trichloroethylene on Female Reproductive Function.
PUB Date Free Form c1984
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 510224062
Origin NTIS
Type CAT