| Main Title |
Neurophysiological Effects of 30 Day Chronic Exposure to Toluene in Rats. |
| Author |
Dyer, R. S. ;
Muller, K. E. ;
Janssen, R. J. ;
Barton, C. N. ;
Boyes, W. K. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/254; |
| Stock Number |
PB85-176626 |
| Additional Subjects |
Toluene ;
Toxicology ;
Bioassay ;
Neurophysiological effects ;
Exposure ;
Rats ;
Laboratory animals ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-176626 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Long-Evans hooded rats were exposed to 1000 ppm toluene or 0 ppm toluene 6 hr/day, 5 days/week for 30 days. Following removal from the exposure conditions (18-26 hr) flash-evoked potentials were recorded to paired light flashes and pentylenetetrazol (PTZ) seizure properties were examined. No alterations were found in the response to the first flash, but alterations in the recoverability of the nervous system were demonstrated by significant latency shifts in the response to the second of the paired flashes, using first flash latencies as covariates. No significant alterations were found in PTZ seizures. The data indicated that at these exposure levels toluene produced a small but significant alteration in brain function, even after toluene had been completely metabolized. |
| Supplementary Notes |
Prepared in cooperation with North Carolina Univ. at Chapel Hill, and Northrop Services, Inc., Research Triangle Park, NC. |
| Availability Notes |
Pub. in Neurobehavioral Toxicology and Teratology, v6 n5 p363-368 Sep 84. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Neurophysiological Effects of 30 Day Chronic Exposure to Toluene in Rats. |
| PUB Date Free Form |
c1984 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
514426747 |
| Origin |
NTIS |
| Type |
CAT |
