| Main Title |
Investigations of Amitraz Neurotoxicity in Rats. 1. Effects on Operant Performance (Journal Version). |
| Author |
Moser, V. C. ;
Boyes, W. K. ;
MacPhail, R. C. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
1987 |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/402; |
| Stock Number |
PB89-105910 |
| Additional Subjects |
Toxicology ;
Rats ;
Laboratory animals ;
Reprints ;
Neurotoxicity ;
Amitraz ;
Operant performance
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105910 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Amitraz (AMZ), a formamidine pesticide, displayed a unique spectrum of neurobehavioral effects which differed from that of the prototypic formamidine, chlordimeform (CDM). In male Long-Evans rats, general signs of intoxication included hypothermia, hyperreactivity, vasodilation, profound weight loss, aggression, and extreme reactions to handling. These effects required days to weeks for recovery, and were cumulative with short-term repeated administration. AMZ produced differential effects on multiple-schedule performance that were distinct from the effects of CDM. Moreover, the marked signs of intoxication, and effects on schedule-controlled behavior following high doses (>50 mg/kg), were persistent and cumulative on repeated administration. |
| Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v9 p131-139 1987. See also PB88-160684. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Investigations of Amitraz Neurotoxicity in Rats. 1. Effects on Operant Performance (Journal Version). |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
834421986 |
| Origin |
NTIS |
| Type |
CAT |
