Main Title |
Cholinergic Involvement in the Action of Formetanate on Operant Behavior in Rats. |
Author |
Moser, V. C. ;
MacPhail, R. C. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/030; |
Stock Number |
PB87-198453 |
Additional Subjects |
Carbamates ;
Insecticides ;
Conditioned responses ;
Sense organs ;
Rats ;
Scopolamine ;
Toxicity ;
Reprints ;
Receptors(Cholinergic) ;
Conditioning(Operant) ;
Receptors(Muscarinic)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-198453 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Formetanate (FMT) is a formamidine acaricide/insecticide with a carbamate moiety in its molecular structure. FMT-induced lethality is reportedly due to inhibition of acetylcholinesterase. Here evidence is reported of the neurochemical basis for the sublethal, behavioral effects of FMT in rats. Injections of scopolamine and methylscopolamine 15 min before FMT blocked the response rate suppression, whereas pretreatment with either mecamylamine or hexamethonium did not. These data suggest that FMT acts as an indirect agonist on central and peripheral muscarinic receptors, by inhibiting acetylcholinesterase, to produce changes in schedule-controlled responding. |
Supplementary Notes |
Pub. in Pharmacology, Biochemistry and Behavior, v26 p119-121 1987. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Cholinergic Involvement in the Action of Formetanate on Operant Behavior in Rats. |
PUB Date Free Form |
1987 |
Category Codes |
68E; 68G; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
723226595 |
Origin |
NTIS |
Type |
CAT |