| Main Title |
Applications of a Neurobehavioral Screening Battery. |
| Author |
Moser., V. C. ;
|
| CORP Author |
NSI Technology Services Corp., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA-68-02-4450; EPA/600/J-92/152; |
| Stock Number |
PB92-179787 |
| Additional Subjects |
Nervous system ;
Toxicology ;
Toxic substances ;
Behavior ;
Rats ;
Dose-response relationships ;
Physiology ;
Reprints ;
Neurobehavioral test battery
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-179787 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
With the growing awareness of the neurological effects of many environmental chemicals, there is considerable emphasis being placed on the detection of neurotoxic potential at the screening, or first-tier, level of testing. The authors have developed a neurobehavioral screening battery consisting of a functional observational battery (FOB) and an automated measure of motor activity which can be incorporated into neuropathological studies as well as general toxicity assessments of new and existing chemicals in rats. This approach has been recommended by several expert national and international panels, and has recently been recommended by the US Environmental Protection Agency for testing pesticides and industrial chemicals. The FOB consists of a series of home-cage, open-field, and interactive assessments of the rat's behavior and neurological functions. Motor activity provides an objective apical measure of the rat's neurobehavioral function. In order to assess validity, sensitivity, and specificity, the authors have utilized these test methods to determine dose-response and time-course characteristics of a wide variety of chemicals including pesticides, metals, solvents, and industrial compounds. |
| Supplementary Notes |
Pub. in Jnl. of the American College of Toxicology, v10 n6 p661-669 Dec 91. See also PB90-113192 and PB91-117101. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Applications of a Neurobehavioral Screening Battery. |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
217730720 |
| Origin |
NTIS |
| Type |
CAT |
