| Main Title |
New Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity. |
| Author |
Clive, D. ;
Caspari, W. ;
Kirby, P. E. ;
Krehl, R. ;
Moore, M. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. |
| Year Published |
1986 |
| Report Number |
EPA/600/D-85/284; |
| Stock Number |
PB86-152246 |
| Additional Subjects |
Bioassay ;
Toxicology ;
Standards ;
Criteria ;
Cells(Biology) ;
Mammals ;
Mice ;
Laboratory animals ;
Mutagenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-152246 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
27p |
| Abstract |
The purpose and scope of the standard guide is to present background material and to establish criteria by which protocols and procedures for conducting the L5178Y/TK+/- -3.7.2C mouse lymphoma mutagenicity assay (MLA) can be properly understood and evaluated. These guidelines are also intended to aid researchers and others to gain a better understanding of the critical elements involved with mammalian cell mutagenicity testing. More specifically, the document is intended to provide a guide to researchers that will accomplish the following goals: Provide an understanding of the critical procedures (steps) involved in the performance of the mammalian cell mutagenicity test; Provide generalized criteria by which researchers can evaluate if they are properly performing, utilizing, and interpreting the assay; Provide criteria by which individuals responsible for evaluating mouse lymphoma mutagenicity data can determine if the experiments have been properly performed and interpreted. |
| PUB Date Free Form |
Jan 86 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
610122125 |
| Origin |
NTIS |
| Type |
CAT |
