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Main Title T Cell Activation by CD1 and Lipid Antigens [electronic resource] /
Author Moody, D. Branch.
Publisher Springer Berlin Heidelberg,
Year Published 2007
Call Number QR180-189.5
ISBN 9783540695110
Subjects Medicine ; Immunology
Internet Access
Description Access URL
Collation VII, 348 p. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes Molecular Biology -- Evolutionary Biology of CD1 -- Architecture of CD1 Proteins -- Structure and Biology of Self Lipid Antigens -- Structures and Functions of Microbial Lipid Antigens Presented by CD1 -- Cellular Biology -- CD1 Expression on Antigen-Presenting Cells -- Pathways of CD1 and Lipid Antigen Delivery, Trafficking, Processing, Loading, and Presentation -- TCR-Mediated Recognition of Glycolipid CD1 Complexes -- Development and Selection of V?14i NKT Cells -- Disease -- CD1-Restricted T Cells in Host Defense to Infectious Diseases -- NKT Cells and Autoimmune Diseases: Unraveling the Complexity -- iNKT Cells in Allergic Disease -- CD1-Restricted T Cells and Tumor Immunity -- Harnessing NKT Cells for Therapeutic Applications. For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipids into a hydrophobic groove on the distal surface of the protein, forming CD1-lipid complexes that act as ligands for T cell receptors. CD1-reactive T cells with conserved (NK T cells) or diverse T cell receptors possess cytokine secretion and other effector mechanisms that influence many aspects of immune response. There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. These features of CD1 antigen presentation systems now point to a new and expanded view of the natural function of ab T cells, which involves surveillance of both the protein and lipid components of target cells. Further, cellular systems that were previously considered to have functions in lipid metabolism can now be studied in context of their immunological functions. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.
Place Published Berlin, Heidelberg
Corporate Au Added Ent SpringerLink (Online service)
Title Ser Add Ent Current Topics in Microbiology and Immunology, 314
Host Item Entry Springer eBooks
PUB Date Free Form 2007
Series Title Untraced Current Topics in Microbiology and Immunology, 314
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20140828063310
Language eng
OCLC Rec Leader 03575nam a22004215i 45