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OLS Field Name OLS Field Data
Main Title In Vitro and In Vivo mutagenicity studies of environmental chemicals /
Author Jones, D. C. L. ; Simmon, V. F. ; Mortelmans, K. E. ; Mitchell, A. D. ; Evans, E. L.
Other Authors
Author Title of a Work
Jones, David C. L.
CORP Author SRI International, Menlo Park, CA.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1984
Report Number EPA/600/1-84/003; EPA-68-02-2947
Stock Number PB84-138973
Subjects Pesticides and wildlife--United States. ; Mutagenicity testing.
Additional Subjects Pesticides ; Toxicology ; In vitro analysis ; In vivo analysis ; Cells(Biology) ; Bacteria ; Bioassay ; Mutagenesis ; Toxic substances ; Ames test
Holdings
Library Call Number Additional Info Location Last
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Checkout
Status
NTIS  PB84-138973 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 583 pages ; 28 cm
Abstract The objectives of this project were to evaluate the mutagenicity of various compounds, mostly pesticides, using microbial and mammalian cell in vitro techniques, as well as in vivo techniques in Drosophila and mice, and to further develop and refine these procedures for application as test batteries. Seventy-nine compounds were evaluated for mutagenicity in one or more of 11 test systems: Salmonella typhimurium plate incorporation assay; E. coli WP-2 reverse mutation assay; S. cerevisiae D3 mitotic recombination assay; Saccharomyces cerevisiae D7 assays; Escherichia Coli, Bacillus subtilis, and S. typhimurium relative toxicity assays; siter-chromatid exchange in Chinese hamster ovary cells assay; L5178Y mouse lymphoma cell forward mutation assay; unscheduled DNA synthesis assay; mouse micronucleus assay; Drosophila sex-linked recessive lethal assay; and mouse dominant lethal assay. The data from the evaluation of 41 pesticides and 10 industrial chemicals are presented in this report. Qualitative interpretations of these data and of data obtained under a previous contract, including those for an additional 28 pesticides, are summarized.
Notes Distributed to depository libraries in microfiche. "January 1984." Includes bibliographical references. "EPA-600/1-84-003." Microfiche.
Place Published Research Triangle Park, NC :
Corporate Au Added Ent Health Effects Research Laboratory (Research Triangle Park, N.C.)
PUB Date Free Form 1984.
NTIS Prices PC A25/MF A01
BIB Level m
Cataloging Source OCLC/T
OCLC Time Stamp 20011213183031
Language eng
Origin NTIS
Type MERGE
OCLC Rec Leader 01165nam 2200289Ka 45020