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OLS Field Name OLS Field Data
Main Title Evaluating the Toxicity of Urban Patterns of Oxidant Gases. 2. Effects in Mice from Chronic Exposure to Nitrogen Dioxide.
Author Miller, F. J. ; Graham, J. A. ; Raub, J. A. ; Illing, J. W. ; Menache, M. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/097;
Stock Number PB88-139969
Additional Subjects Toxicology ; Nitrogen ; Urban areas ; Exposure ; Mice ; Laboratory animals ; Bioassay ; Reprints ; Air pollution effects
Library Call Number Additional Info Location Last
NTIS  PB88-139969 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 16p
Abstract The study reported herein evaluates the influence of a chronic exposure to an urban pattern of NO2 (continuous baseline exposure of 0.2 ppm on which were superimposed two 1-hr spikes of 0.8 ppm NO2, 5 days/wk) as compared to the baseline exposure to determine the contribution of the spikes to toxicity. Mice were exposed for up to 52 wk with interim examinations. Multivariate analysis of variance revealed a statistically significant treatment effect on infectivity (p=0.05) and pulmonary function (p=0.03) parameters. Infectivity mortality of mice in the spiked exposure regimen was significantly greater than that in either the NO2-background exposed mice or in control mice. Four of the pulmonary function variables exhibited the greatest differences among the treatment groups: end expiratory volume, vital capacity, respiratory system compliance, and multiple-breath nitrogen washout. Results from the pulmonary function analyses indicate that the spiked exposures to 0.8 ppm NO2 may have induced a subtle lesion. The chronic study results indicate that the presence of spikes of NO2 is contributing significantly to effects on antibacterial lung defenses and pulmonary function of mice.
Supplementary Notes Pub. in Jnl. of Toxicology and Environmental Health, v21 p99-112 1987. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Evaluating the Toxicity of Urban Patterns of Oxidant Gases. 2. Effects in Mice from Chronic Exposure to Nitrogen Dioxide.
PUB Date Free Form c1987
Category Codes 57Y; 68A
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 807117277
Origin NTIS
Type CAT