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OLS Field Name OLS Field Data
Main Title Cerebellar Hypoplasia in the Gunn Rat is Associated with Quantitative Changes in Neurotypic and Gliotypic Proteins.
Author O'Callaghan , J. P. ; Miller, D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/410;
Stock Number PB86-214871
Additional Subjects Proteins ; Bioassay ; Rats ; Laboratory animals ; Morphology ; Behavior ; Reprints ; Neurotoxicity ; Cerebellar hypoplasia
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NTIS  PB86-214871 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 14p
Abstract The authors are characterizing toxicant-induced injury to the nervous system by measuring nervous system cell-type specific proteins together with accompanying changes in morphology and behavior. In the present study, cerebellar neurotoxicity was assessed in the Gunn rat an autosomal recessive mutant that exhibits degeneration of Purkinje cells due to hereditary hyperbilirubinemia. Five proteins associated with neuronal or glial cell types were chosen for evaluation as follows: (1) G-substrate, a Purkinje cell-specific phosphoprotein that serves as the endogenous substrate of cyclic GMP-dependent protein kinase; (2) PCPP-260, a Purkinje cell-specific phosphoprotein that serves as an endogenous substrate of cyclic AMP-dependent protein kinase; (3) synapsin I, a synapse-specific phosphoprotein present in all neurons; (4) glial fibrillary acidic protein, an astrocyte-specific protein; and (5) myelin basic protein, a protein unique to myelin.
Supplementary Notes Pub. in Jnl. of Pharmacology and Experimental Therapeutics, v234 n2 p522-533 Aug 85. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Cerebellar Hypoplasia in the Gunn Rat is Associated with Quantitative Changes in Neurotypic and Gliotypic Proteins.
PUB Date Free Form c1985
Category Codes 6O; 57Q
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 624112949
Origin NTIS
Type CAT