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RECORD NUMBER: 24 OF 94| Main Title | Effects of Chemically Induced Maternal Toxicity on Prenatal Development in the Rat. | |||||||||||
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| Author | Chernoff, N. ; Setzer, R. W. ; Miller, D. B. ; Rosen, M. B. ; Rogers, J. M. ; | |||||||||||
| CORP Author | Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;Northrop Services, Inc., Research Triangle Park, NC. | |||||||||||
| Publisher | c1990 | |||||||||||
| Year Published | 1990 | |||||||||||
| Report Number | EPA/600/J-92/074; | |||||||||||
| Stock Number | PB92-150887 | |||||||||||
| Additional Subjects | Teratogens ; Toxicity ; Fetal development ; Maternal-fetal exchange ; Diquat ; Toxaphene ; Styrene ; Organotin compounds ; Cacodylic acid ; Dose-response relationships ; Reprints ; Rats ; Supernumerary ribs ; Ethylene-bis-isothiocyanate ; Dichlorophenoxyacetic acids ; Trichlorophenols | |||||||||||
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| Collation | 10p | |||||||||||
| Abstract | The hypothesis that chemically induced overt maternal toxicity induces a characteristics syndrome of adverse developmental effects in the rat was investigated. Pregnant animals (Sprague-Dawley strain) were dosed by oral gavage with one of a series of compounds on days 6-15 of gestation. These chemicals were diquat (DIQ), ethylene-bis-isothiocyanate (EBIS), toxaphene (TOX), styrene (STY), 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenol (2,4,5-Tr), triphenyl tin hydroxide (TPTH), and cacodylic acid (CAC). Significant maternal weight reductions were noted during the course of treatment with all compounds except CAC and 2,4,5-Tr. Maternal lethality was produced by EBIS, TOX, 2,4,-D, and 2,4,5-Tr. The main treatment-related developmental toxicity noted in litters at term consisted of increased lethality (EBIS, TPTH) and decreased fetal weight (EBIS and CAC). Treatment-related anomalies were seen in litters treated with 2,4-D and TOX (supernumerary ribs) and with EBIS and STY (enlarged renal pelvis). No significant developmental effects were produced with DIQ, or 2,4,5-Tr. The study indicates that overt maternal toxicity as defined by weight loss or mortality is not always associated with the same defined syndrome of adverse developmental effects in the rat. | |||||||||||
| Supplementary Notes | Pub. in Teratology, v42 n6 p651-658 Dec 90. See also PB89-103980. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. | |||||||||||
| NTIS Title Notes | Journal article. | |||||||||||
| Title Annotations | Reprint: Effects of Chemically Induced Maternal Toxicity on Prenatal Development in the Rat. | |||||||||||
| Category Codes | 57Y; 57S | |||||||||||
| NTIS Prices | PC A02/MF A01 | |||||||||||
| Primary Description | 600/10 | |||||||||||
| Document Type | NT | |||||||||||
| Cataloging Source | NTIS/MT | |||||||||||
| Control Number | 211523010 | |||||||||||
| Origin | NTIS | |||||||||||
| Type | CAT |