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RECORD NUMBER: 58 OF 338

Main Title Concentration of Glial Fibrillary Acidic Protein Increases with Age in the Mouse and Rat Brain.
Author O'Callaghan, J. P. ; Miller, D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/250;
Stock Number PB92-110535
Additional Subjects Glial fibrillary acidic protein ; Brain chemistry ; Aging(Biology) ; Mice ; Rats ; Corpus striatum ; Synapsins ; Neurofilament proteins ; Species specificity ; Monoclonal antibodies ; Radioimmunoassay ; Reprints ;
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NTIS  PB92-110535 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Abstract The role of aging in the expression of the astrocyte protein, glial fibrillary acidic protein (GFAP), was examined. In both mice and rats the concentration of GFAP increased throughout the brain as a function of aging. The largest increase (2-fold) was observed in striatum for both species. The neuron-specific proteins, synapsin I and neurofilament-200 were not altered by aging in any region of the mouse or rat brain. The data suggest that strocytic hypertrophy observed with aging involves an accumulation of glial filaments.
Supplementary Notes Pub. in Neurobiology of Aging, v12 n3 p171-174 May 91.
NTIS Title Notes Journal article.
Title Annotations Reprint: Concentration of Glial Fibrillary Acidic Protein Increases with Age in the Mouse and Rat Brain.
Category Codes 57F; 57S
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 133921381
Origin NTIS
Type CAT