Main Title |
Neuron-Specific Phosphoproteins as Biochemical Indicators of Neurotoxicity: Effects of Acute Administration of Trimethyltin to the Adult Rat. |
Author |
O'Callaghan, J. P. ;
Miller, D. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1984 |
Report Number |
EPA/600/J-84/263; |
Stock Number |
PB85-193654 |
Additional Subjects |
Central nervous system ;
Rats ;
Reprints ;
Neurotoxins ;
Phosphoproteins ;
Trimethyltin compounds
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-193654 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The cytoarchitecture of the adult central nervous system is expressed by proteins specific to individual cell types. In this investigation, a subclass of these proteins, the neuron-specific phosphoproteins, was examined after the administration of trimethyltin (TMT), a neurotoxicant which preferentially damages neurons in limbic structures. After acute administration of TMT, effects on neuronal phosphoproteins were examined by three separate techniques: (1) endogenous phosphorylation of total synaptic membrane proteins; (2) radiometric assay of synapsin I, a neuron-specific phosphoprotein associated with synaptic vesicles; and (3) radioimmunoassay of synapsin I and protein III, another synapsin specific, synaptic vesicle-localized phosphoprotein. The authors findings are consistent with the neuropathological effects of this compound and suggest that neuron-specific phosphoproteins may be useful biochemical indicators of neurotoxicity. |
Supplementary Notes |
Pub. in Jnl. of Pharmacology and Experimental Therapeutics, v231 n3 p736-743 Dec 84. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Neuron-Specific Phosphoproteins as Biochemical Indicators of Neurotoxicity: Effects of Acute Administration of Trimethyltin to the Adult Rat. |
PUB Date Free Form |
1984 |
Category Codes |
6T; 57Y; 57F |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
519921960 |
Origin |
NTIS |
Type |
CAT |