| Main Title |
Mathematical Modeling of Ozone Absorption in the Lower Respiratory Tract. |
| Author |
Overton, J. ;
Graham, R. C. ;
Miller, F. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/D-88/141; |
| Stock Number |
PB88-225073 |
| Additional Subjects |
Toxicology ;
Ozone ;
Adsorption ;
Respiratory systems ;
Mathematical models ;
Air pollution ;
Chemical reactions ;
Inhalation ;
Dosimetry models
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-225073 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
A mathematical O3 dosimetry model has been developed for simulating the local absorption of O3 in the lower respiratory tract (LRT) of animals and man. The model takes into account LRT anatomy, transport in the lumen and air spaces, transport and chemical reactions in the liquid layers and in the underlying tissue and capillaries. Differential equations are used to describe the processes of transport and chemical reactions; solutions are obtained numerically. Simulations are illustrated with results of two investigations: the effect of anatomical models on predicted LRT uptake of O3 in rat and guinea pig, and the effect of exercise on the uptake and distribution of ozone in the LRT of man. |
| Supplementary Notes |
Pub. in Pharmacokinetics in Risk Assessment: Drinking Water and Health, v8 p302-311 1987. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
| PUB Date Free Form |
1987 |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
826018133 |
| Origin |
NTIS |
| Type |
CAT |
