Main Title |
Four-Week Inhalation Toxicity Study of Cyclopropanemethanol in Rats. (Preliminary Results). |
Author |
Miller, K. R. ;
|
CORP Author |
Eastman Chemical Co., Kingsport, TN. ;Eastman Kodak Co., Rochester, NY. Health and Environment Labs.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Publisher |
12 Nov 2001 |
Year Published |
2001 |
Report Number |
8EHQ-0502-13706; EPA-89020000116 |
Stock Number |
OTS-0558579-3 |
Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Cyclopropanemethanol ;
Subchronic toxicity ;
Mammals ;
Rats ;
Inhalation ;
CAS No 2516-33-8 ;
Inhalation exposure ;
Toxicity ;
Weight ;
Food consumption
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS-0558579-3 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
283p |
Abstract |
Male and female Sprague-Dawley rats were exposed to target vapor concentrations of 0.100, 0.035, 0.003, or 0 mg/L (34, 12, 1, or 0ppm) of the test substance 6 hours per day, 5 days per week (excluding one holiday) for 21 exposures. Five animals per sex per group were terminated the day after the last exposure. An additional five animals per sex from the 0.100 and 0 mg/L groups were allowed to recover for 14 days following the exposure period. All animals survived to scheduled sacrifice. Animals were observed for clinical signs of toxicity each morning, once per hour during each exposure, and immediately after termination of each exposure. No test substance-related clinical abnormalities were observed. Body weights and feed consumption were measured weekly. Mean body weight, body weight gains, feed consumption, and fee utilization were comparable among the groups throughout the study. On Day 30 the main study animals were anesthetized with Isoflurane and blood were obtained from the posterior vena cava for clinical chemistry analyses. Fasted body weights and selected organ weights were measured at necropsy. Selected tissues were collected from all animals. On Day 44, the recovery animals were anesthetized, bled, and necropsied in the same manner as the main study animals. The mean urea nitrogen level was higher (p less than or equal to 0.05) for the main study 0.100 mg/L female group when compared with the control group. All other clinical chemistry parameters for the main study and recovery animals were comparable among the groups. Mean terminal body weights and absolute and relative (to body weight) organ weights for the main study and recovery animals were comparable among the groups. |
Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Eastman Kodak Co., Rochester, NY. Health and Environment Labs. |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
Category Codes |
57E; 57Y |
NTIS Prices |
PC A14/MF$25.00 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
005100290 |
Origin |
NTIS |
Type |
CAT |