| Main Title |
Bupropion, d-Amphetamine, and Amitriptyline-Induced Conditioned Taste Aversion in Rats: Dose Effects. |
| Author |
Miller, D. B. ;
Miller, L. L. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Burroughs Wellcome Co., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-600/J-83-128; |
| Stock Number |
PB84-144294 |
| Additional Subjects |
Rats ;
Dosage ;
Chlorine organic compounds ;
Organic sulfates ;
Reprints ;
Bupropion hydrochloride ;
Amphetamine sulfate ;
Amitriptyline hydrochloride ;
Phenethylamines ;
Propanone/(chlorophenyl)-((dimethylethyl)amino)-(hydrochloride) ;
CAS 31677-93-7 ;
Propanamine/(dihydro-dibenzocycloheptenylidene)-N-N-dimethyl-(hydrochloride) ;
CAS 60-13-9 ;
CAS 549-18-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-144294 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
Nine groups of rats (n+6 per group) were adapted to a daily one-half hour period of water availability. When intake had stabilized, they were allowed access to a 0.1% (w/v) solution of saccharin, and immediately afterward were given IP injections of isotonic saline; bupropion HCl (10.0, 20.0, or 40.0 mg/kg); d-amphetamine-sulfate (0.5, 1.0, 2.0 mg/kg); or amitriptyline HCl (5.0, 10.0, or 20.0 mg/kg); in a volume of 1 ml. The lowest dose of each compound was chosen to be equipotent in screening tests used to identify potential antidepressants. Following 2 days of access to water alone, all groups were given a choice between water and saccharin for 3 consecutive days. All compounds induced taste aversions in a dose-related manner, but amitriptyline induced greater and longer-lasting aversions than either bupropion or d-amphetamine which were equipotent over the dose range studied. |
| Supplementary Notes |
Prepared in cooperation with North Carolina Univ. at Chapel Hill and Burroughs Wellcome Co., Research Triangle Park, NC. |
| Availability Notes |
Pub. in Pharmacology Biochemistry and Behavior, v18 p737-740 1983. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Bupropion, d-Amphetamine, and Amitriptyline-Induced Conditioned Taste Aversion in Rats: Dose Effects. |
| PUB Date Free Form |
1983 |
| Category Codes |
6O; 6A; 57Q; 57B |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
409019490 |
| Origin |
NTIS |
| Type |
CAT |
