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Main Title Extrapulmonary Effects of NO2 as Reflected by Pentobarbital-Induced Sleeping Time in Mice.
Author Miller, Frederick J. ; Graham, Judith A. ; Illing, Joseph W. ; Gardner, Donald E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-600/J-80-254;
Stock Number PB81-192072
Additional Subjects Nitrogen dioxide ; Pentobarbital ; Toxicology ; Barbiturates ; Mice ; Laboratory animals ; Exposure ; Sleep ; Concentration(Composition) ; Males ; Females ; Reprints ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB81-192072 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Abstract The influence of nitrogen dioxide (NO2) on pentobarbital(PEN)-induced sleeping time (S.T.) was investigated in mice. Acute exposure to concentrations as low as 470 micrograms NO2/cu m (0.25 ppm) caused a significant increase in PEN-induced S.T. No significant effects on PEN-induced S.T. were detected after 1 or 2 days (3 h/day) exposure to 235 micrograms NO2/cu m (0.125 ppm). None of the exposure regimens affected the time required for the drug to induce sleep. When the effects of repeated daily exposures (3 h/day) to 9400 micrograms NO2/cu m 5 ppm) were compared in male and female mice, the females had a significantly increased PEN-induced S.T. after 1 and 2 days of exposure. However, an increase in PEN-induced S.T. was not observed in males until the 3rd day of exposure. Since the duration of PEN-induced S.T. is primarily determined by hepatic mixed function oxidase activity, it is possible that NO2 may alter some aspects of xenbiotic metabolism.
Supplementary Notes Pub. in Toxicology Letters 6, p267-274 1980.
NTIS Title Notes Journal article.
Title Annotations Reprint: Extrapulmonary Effects of NO2 as Reflected by Pentobarbital-Induced Sleeping Time in Mice.
PUB Date Free Form 22 Apr 80
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323797254
Origin NTIS
Type CAT