| Main Title |
Assessment of Maternal Toxicity, Embryotoxicity and Teratogenic Potential of Sodium Chlorite in Sprague-Dawley Rats. |
| Author |
Couri, Daniel ;
Miller, Jr., Carl H. ;
Bull, Richard J. ;
Delphia, John M. ;
Ammar, Elsayed M. ;
|
| CORP Author |
Ohio State Univ., Columbus. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1982 |
| Report Number |
EPA-R-805643; EPA-600/J-81-363; |
| Stock Number |
PB83-187930 |
| Additional Subjects |
Toxicology ;
Sodium chlorite ;
Rats ;
Laboratory animals ;
Reprints ;
Teratogenesis ;
Embryotoxicity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-187930 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Groups of up to 13 pregnant rats were individually caged. Body weight, food and water consumption were recorded at days 1, 8, 15 and 22 of gestation and the dams were treated on days 8-15 with sodium chlorite, 0.1%, 0.5% or 2% in drinking water or by injection of 10, 20, or 50 mg/kg IP or by gavaging with 200 mg/kg. To prevent ingestion of stillborn pups some dams were sacrificed at day 22. Other dams were allowed to deliver at term. Fetuses were weighed, measured and examined for soft tissue and skeletal malformations. Sodium chlorite, 20 or 50 mg/kg daily IP or gavaging with 200 mg/kg, caused vaginal and urethral bleeding. Doses of 10, 20 or 50 and 100% mortality of dams, respectively. |
| Supplementary Notes |
Pub. in Environmental Health Perspectives, v46 p25-29 1982. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Assessment of Maternal Toxicity, Embryotoxicity and Teratogenic Potential of Sodium Chlorite in Sprague-Dawley Rats. |
| PUB Date Free Form |
1982 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
320321914 |
| Origin |
NTIS |
| Type |
CAT |
