| Main Title |
Lower Respiratory Tract Structure of Laboratory Animals and Humans: Dosimetry Implications. |
| Author |
Miller, F. J. ;
Mercer, R. R. ;
Crapo, J. D. ;
|
| CORP Author |
Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Center for Extrapolation Modelling.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| Publisher |
c1993 |
| Year Published |
1993 |
| Report Number |
EPA-R-813113; EPA/600/J-94/051; |
| Stock Number |
PB94-137031 |
| Additional Subjects |
Respiratory system ;
Humans ;
Animals ;
Anatomy ;
Dosimetry ;
Species diversity ;
Pulmonary alveoli ;
Aerosols ;
Drug administration routes ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-137031 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Significant differences in lower respiratory tract structure exist both within species and among species at each level of anatomy. The effects of these various branching patterns on airflow distribution, gas uptake, and the deposition of particles have not been sufficiently studied to determine the extent to which branching patterns impart regional inhomogeneities or local variations in the deposition of inhaled material. We have been using three-dimensional reconstruction techniques to examine various aspects of lung structure. The new knowledge gained about lung structure and geometry applies to a number of areas. Among these are (a) examining lobar and path-specific deposition patterns for pharmaceutical aerosol distributions, (b) selecting critical sites for potential lung injury, and (c) establishing respiratory tract structure based criteria for the optimum design of pharmaceutical aerosols. |
| Supplementary Notes |
Pub. in Aerosol Science and Technology, v18 n3 p257-271 Apr 93. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Center for Extrapolation Modelling. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Lower Respiratory Tract Structure of Laboratory Animals and Humans: Dosimetry Implications. |
| Category Codes |
57A; 57Q |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
407719884 |
| Origin |
NTIS |
| Type |
CAT |
