| Main Title |
Interactions between Lead and Essential Elements: A Review. |
| Author |
Miller, G. D. ;
Massaro, T. F. ;
Massaro, E. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;Kraft General Foods, Glenview, IL. ;Pennsylvania State Univ., University Park. Office of Sponsored Programs. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/134; |
| Stock Number |
PB91-109728 |
| Additional Subjects |
Lead(Metal) ;
Toxicology ;
Trace elements ;
Reviews ;
Tissues(Biology) ;
Trace elements ;
Biochemistry ;
Physiology ;
Copper ;
Iron ;
Calcium ;
Zinc ;
Ascorbic acid ;
Reprints ;
Vitamin D
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-109728 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
23p |
| Abstract |
Recent clinical evidence indicates that in humans subchronic exposure to Pb during development can result in decreased developmental scores and behavioral alterations in the absence of overt neurotoxicity. The mechanism(s) by which Pb induces such alterations is unknown. Conceivably, the central nervous system (CNS) may be especially sensitive to Pb. On the other hand, deleterious effects of Pb may not be mediated directly by Pb itself. For example, perturbation of CNS function may be a manifestation of essential/trace mineral deficiencies resulting from Pb-induced impairment of mineral availability and/or increased sensitivity of the CNS to Pb intoxication in the absence of adequate levels of essential minerals. Focusing on the role of essential/trace mineral alterations is reasonable since the behavioral sequelae of neonatal Pb exposure often mimic those accompanying specific trace mineral deficiencies during this period of development. The current status of knowledge of the interactions of lead and essential elements is reviewed. (Copyright (c) 1990 by Intox Press, Inc.) |
| Supplementary Notes |
Pub. in NeuroToxicology (Trade Name), v11 p99-120 1990. Prepared in cooperation with Kraft General Foods, Glenview, IL., and Pennsylvania State Univ., University Park. Office of Sponsored Programs. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Interactions between Lead and Essential Elements: A Review. |
| Category Codes |
57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
034834706 |
| Origin |
NTIS |
| Type |
CAT |
