| Main Title |
Effects of Inhalation of Organic Chemical Air Contaminants on Murine Lung Host Defenses. |
| Author |
Aranyi, C. ;
O'Shea, W. J. ;
Graham, J. A. ;
Miller, F. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;IIT Research Inst., Chicago, IL. Life Sciences Research Div. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/177; |
| Stock Number |
PB87-115093 |
| Additional Subjects |
Toxicology ;
Organic compounds ;
Inhalation ;
Lung ;
Reprints ;
Air pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-115093 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
The potential health hazards of exposure to threshold limit value (TLV) concentrations of acetaldehyde, acrolein, propylene oxide, chloroform, methyl chloroform, carbon tetrachloride, allyl chloride, methylene chloride, ethylene trichloride, perchloroethylene, benzene, phenol, monochlorobenzene, and benzyl chloride, compounds which may be present in the ambient or work room atmosphere were investigated. The effects of single and multiple 3-hr inhalation exposures were evaluated in mice by monitoring changes in their susceptibility to experimentally induced streptococcus aerosol infection and pulmonary bactericidal activity to inhaled Klebsiella pneumoniae. When significant changes in these parameters were found, further exposures were performed at reduced vapor concentrations until the no-measurable-effect level was reached. Multiple exposures on 5 consecutive days were then performed at the concentration. Significant increases in susceptibility to respiratory streptococcus infection were observed after single 3-hr exposure to TLV concentrations of methylene chloride, perchloroethylene, and ethylene trichloride. For methylene chloride and perchloroethylene, these exposure conditions also resulted in significantly decreased pulmonary bactericidal activity. (Copyright (c) 1986 Society of Toxicology.) |
| Supplementary Notes |
Pub. in Fundamental and Applied Toxicology 6, p713-720 1986. Prepared in cooperation with IIT Research Inst., Chicago, IL. Life Sciences Research Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of Inhalation of Organic Chemical Air Contaminants on Murine Lung Host Defenses. |
| PUB Date Free Form |
c1986 |
| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
703715354 |
| Origin |
NTIS |
| Type |
CAT |
