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OLS Field Name OLS Field Data
Main Title The mechanism of sulfur dioxide initiated bronchoconstriction /
Author Charles, Jeffrey M. ; Menzel., Daniel B.
Other Authors
Author Title of a Work
Menzel, Daniel B.
Gardner, Donald E.,
Gardner, Donald E., 1931-
CORP Author Duke Univ. Medical Center, Durham, N.C. Lab. of Environmental Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1977
Report Number EPA-600/1-77-046; EPA-68-02-1794; PB275713
Stock Number PB 275 713
OCLC Number 52418644
Additional Subjects Sulfur dioxide ; Sulfates ; Lung ; Respiratory system ; Particles ; Respiration ; Bonchi ; Absorption(Biology) ; Pathophysiology ; Histamines ; In vitro analysis ; Guinea pigs ; In vivo analysis ; Rats ; Laboratory animals ; Clearances ; Ammonium sulfate ; Experimental data ; Physiological effect ; Toxicology ; Air pollution effects(Animals) ; Synergism ; Irritant compounds ; Environmental health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-77-046 Headquarters Library/Washington,DC 06/04/2012
EJBD  EPA 600-1-77-046 Headquarters Library/Washington,DC 05/19/2014
EKBD  EPA-600/1-77-046 Research Triangle Park Library/RTP, NC 06/13/2003
ELBD RPS EPA 600-1-77-046 repository copy AWBERC Library/Cincinnati,OH 07/07/2016
NTIS  PB-275 713 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation xiv, 109 pages : illustrations ; 28 cm.
Abstract Atmospheric sulfur oxides exist in chemically complex particulates of the respirable size range. Inhalation of these particulates represents a potential health hazard. This report provides the results of a series of experiments into the uptake of sulfate salts by the lung, the interaction of sulfate salts with specific hormonal systems in the lung and the potential interrelations between sulfate and heavy metal aerosols as they might exist in the environment. The data reported describe for the first time the uptake and elimination kinetics of sulfate ion in mammalian lungs. The release of histamine by sulfate salts is demonstrated as a potential mechanism of action and as a means by which the varying potency of different chemical salts of sulfuric acid may be explained. In sum, these studies illustrate that sulfate aerosols can not be considered independent of the other inorganic compounds found in respirable particles.
Notes "Project Officer: Donald E. Gardner." Duke University Medical Center "October 1977." "EPA-600/1-77-046." Includes bibliographical references.
Place Published Research Triangle Park, N.C.
Access Notes Also available via the World Wide Web.
Corporate Au Added Ent Health Effects Research Laboratory (Research Triangle Park, N.C.); Duke University. Medical Center.
Title Ser Add Ent Research reporting series. Environmental health effects research ; EPA-600/1-77-044.
PUB Date Free Form 1977
Series Title Traced Environmental health effects research series ; EPA-600/1-77-046
Series Title Untraced Research reporting series. 1, Environmental health effects research ; EPA-600/1-77-046
NTIS Prices PC A07/MF A01
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source OCLC/T
OCLC Time Stamp 20160706054422
Language eng
Origin OCLC
OCLC Rec Leader 01894cam 2200457Ka 45010