||Augmentation of Sulfate Ion Absorption from the Rate Lung by Heavy Metals.
Charles, Jeffrey M. ;
Gardner, Donald E. ;
Coffin, David L. ;
Menzel., Daniel B. ;
||Duke Univ. Medical Center, Durham, N.C.;Health Effects Research Lab., Research Triangle Park, N.C.
Air pollution ;
Laboratory animals ;
Heavy metals ;
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||The effect of heavy metal cations in enhancing the absorption of sulfate ions from the airways of the rat lung was studied. The cations investigated included Cd(2+), Co(2+), Hg(2+), Ni(2+), Fe(3+), Mn(2+), and Zn(2+). The cations exhibited differing efficacies. Co(2+), Hg(2+), Cd(2+), and Ni(2+) produced maximal effect at 0.1 nmol/lung, while Fe(3+) and Zn(2+) were the least effective, reaching maximal effect at 10.0 nmol/lung. An exception was Mn(2+), which did not alter absorption. Hydrogen ion concentrations departing from physiological pH values (4.4-9.4) enhanced sulfate ion absorption. Exposure of rats to a NiCl2 aerosol of 480 micrograms of Ni/cu m for 2 hr prior to the determination of sulfate ion absorption led to a 12.0 plus or minus 2.7% enhancement of absorption. These results suggest a possible correlation between the irritant potential associated with inhalation of a specific sulfate salt and the rate at which sulfate ions are absorbed from the lung. (Copyright (c) 1977 by Academic Press, Inc.)
||Pub. in Toxicology and Applied Pharmacology 42, p531-438 1977.
|NTIS Title Notes
||Reprint: Augmentation of Sulfate Ion Absorption from the Rate Lung by Heavy Metals.
|PUB Date Free Form
||16 Jul 77
||6T; 6P; 57Y; 57S; 68G; 68A
||Not available NTIS