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Main Title Chemical Activation of Non-Mutagenic Nitrated Polycyclic Aromatic Hydrocarbons to Mutagens.
Author Karpinsky, G. E. ; McCoy, E. C. ; Rosenkranz, H. S. ; Mermelstein, R. ;
CORP Author Case Western Reserve Univ., Cleveland, OH. ;Xerox Corp., Rochester, NY.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA/600/J-82/457;
Stock Number PB86-185519
Additional Subjects Mutagens ; Nitro compounds ; Aromatic polycyclic hydrocarbons ; Carcinogens ; Reduction(Chemistry) ; Bacteria ; Enzymes ; Hydroxylamine ; Salmonella typhimurium ; Reprints ; Chemical activation
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NTIS  PB86-185519 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Abstract Nitrated polycyclic aromatic hydrocarbons, including carcinogens, may be non-mutagenic in microorganisms because bacterial nitroreductases are unable to reduce their nitro function to proximate mutagenic hydroxylamines. The reduction of the nitro moiety can be accomplished chemically in situ using zinc dust. The procedure, which is compatible with the Salmonella mutagenicity assay, was used to generate mutagens from chemicals which otherwise are non-mutagenic even in the presence of microsomal preparations.
Supplementary Notes Pub. in Mutation Research 92, n1/2 p29-37 Feb 82. Prepared in cooperation with Xerox Corp., Rochester, NY. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Chemical Activation of Non-Mutagenic Nitrated Polycyclic Aromatic Hydrocarbons to Mutagens.
PUB Date Free Form c1982
Category Codes 6T; 6A; 57Y; 57B
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 618817627
Origin NTIS
Type CAT