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Main Title Membrane Microdomain Signaling Lipid Rafts in Biology and Medicine / [electronic resource] :
Author Mattson, Mark P.
Publisher Humana Press,
Year Published 2005
Call Number QH573-671
ISBN 9781592598038
Subjects Life sciences ; Cytology
Internet Access
Description Access URL
Collation X, 214 p. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes From Intramolecular Asymmetries to Raft Assemblies -- Regulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells -- Lipid Raft Membrane Skeletons -- Role of Cholesterol in Membrane Microdomain Signaling -- Raft Lipid Metabolism in Relation to Alkyl-Lysophospholipid-Induced Apoptosis -- The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells -- Role of Rafts in Virus Fusion and Budding -- Alterations in Raft Lipid Metabolism in Aging and Neurodegenerative Disorders -- Caveolin and Cancer -- Dietary Modulation of Lipid Rafts. Lipid rafts-discrete regions in cell membranes that are rich in cholesterol and sphingolipids-are emerging not only as pivotal command and control centers for cellular signaling processes, but also as central to a wide array of human diseases, including immune disorders, diabetes, cardiovascular disease, and Alzheimer's disease. In Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine, multidisciplinary experts offer cutting-edge reviews of our current understanding of these membrane microdomains and their physiological and pathological roles. Here, readers will discover how lipid rafts change in cells over time and how they respond to various environmental signals, how cholesterol modulates the signaling function of lipid rafts, and how lipid rafts, the extracellular matrix, and the cell cytoskeleton structurally interact. Also described are the role of lipid rafts in learning, memory, and cancer, and as portals for endocytic uptake of an anticancer- and apoptotic alkyl-lysophospholipid. The authors also present emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and that alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. They also describe techniques for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts. Comprehensive and insightful, Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine offers researchers a multidisciplinary review of the latest basic, translational, and clinical research that promises to transform our understanding microdomain signaling mechanisms.
Place Published Totowa, NJ
Corporate Au Added Ent SpringerLink (Online service)
Host Item Entry Springer eBooks
PUB Date Free Form 2005
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20140726053506
Language eng
OCLC Rec Leader 03624nam a22003975i 45