Main Title |
Arterial Blood Gases, Pulmonary Function and Pathology in Rats Exposed to 0.75 or 1.0 ppm Ozone. |
Author |
Pepelko, William E. ;
Mattox, Joan K. ;
Yang, You Yen ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
Year Published |
1980 |
Report Number |
EPA-600/J-80-179; |
Stock Number |
PB81-148454 |
Additional Subjects |
Ozone ;
Toxicology ;
Rats ;
Laboratory animals ;
Pathology ;
Exposure ;
Body weight ;
Blood gas analysis ;
Respiratory system ;
Reprints ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB81-148454 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
Arterial blood gases, residual lung volume (RV), deflation pressure volume (PV) curves, pulmonary pathology and body weight changes were studied in rats exposed up to 14 days to either 0.75 or 1.0 ppm ozone. Arterial PO2 and body weights decreased progressively with length of exposure while PaCO2 and RV increased. The slope of the PV curve decreased in all groups exposed to ozone. Pathological changes in the lung increased in severity with concentration and length of exposure. The present findings have shown that arterial blood gas measurements represent a sensitive index of altered lung function in rats, a species very sensitive to ozone exposure. |
Supplementary Notes |
Pub. in Jnl. of Environmental Pathology and Toxicology 3, p247-259 1980. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Arterial Blood Gases, Pulmonary Function and Pathology in Rats Exposed to 0.75 or 1.0 ppm Ozone. |
PUB Date Free Form |
1980 |
Category Codes |
6T; 6E; 57Y; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323791349 |
Origin |
NTIS |
Type |
CAT |