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Main Title Age-Dependent Lung Dosimetry of Radon Progeny.
Author Hofmann, W. ; Martonen, T. B. ; Menache, M. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.
Year Published 1988
Report Number EPA/600/D-88/027;
Stock Number PB88-170121
Additional Subjects Radon ; Dosimetry ; Lung ; Models ; Risk ; Respiratory diseases ; Carcinogens ; Morphology ; Ionizing radiation ; Dose rate ;
Library Call Number Additional Info Location Last
NTIS  PB88-170121 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 48p
Abstract Two morphometric models differing in the tracheobronchial region, were compared in the present paper: Model 1 is based on the adult morphology of Weibel, assuming that all bronchial airways grow in equal proportion; while Model 2 adopts the adult structure proposed by Yeh and Schum, using measured airway dimensions in the right upper lobe as a function of age. Tidal volume and respiratory frequency also vary with age: while the breathing frequency decreases with rising age, tidal volume increases. Radiation doses in each bronchial airway generation were computed for the deep lying basal cells as well as for the more uniformly distributed serous (SMGS) cells, which are currently assumed to be the progenitor cells for bronchial carcinomas. Radiation doses to both target cells were significantly higher in the newborn than in the adult, for all simulated breathing patterns, showing the highest relative increase in upper bronchial airways. Comparing both tracheobronchial growth models, Model 1 predicts higher doses at early ages, but produced lower doses in the adult lung.
Supplementary Notes Prepared in cooperation with Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC., and Duke Univ. Medical Center, Durham, NC.
PUB Date Free Form Feb 88
Category Codes 57V; 57Y; 99E
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 811327159
Origin NTIS
Type CAT