||Definition of Airway Composition Within Gamma Camera Images.
Martonen, T. B. ;
Yang, Y. ;
Dolovich, M. ;
Eng, P. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;McMaster Univ., Hamilton (Ontario).
Gamma cameras ;
Inhalation administration ;
Pulmonary alveoli ;
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||The authors present an analytical model to assist the clinician in the systematic analysis and interpretation of gamma camera images to aid in assessing the efficacies of inhaled pharmacologic drugs in the prophylaxis and treatment of airway diseases. Using the Cray Y-MP supercomputer, a range of human lung morphologies has been mapped to function as templates that can be superimposed on scans. The model is intended to complement laboratory regimens by providing a previously unavailable method to define the C, I, and P zones of the human lung generation by generation. A quantitative value now can be assigned to the degree of overlappng that exists in the images. For example, for a typical lung morphology consisting of 16,777,215 airways (total), the C zone itself may contain 1,608,246 airways, of which 1,595,940, or 99.2%, are alveolated airways. By identifying composition, the authors' intent is to integrate the model into future aerosol therapy protocols and thereby assist procedures that target delivery of airborne pharmaceuticals.
||Color illustrations reproduced in black and white. Pub. in Jnl. of Thoracic Imaging 9, n3 p188-197 Jul 94. Prepared in cooperation with North Carolina Univ. at Chapel Hill. and McMaster Univ., Hamilton (Ontario).
|NTIS Title Notes
||Reprint: Definition of Airway Composition Within Gamma Camera Images.
||PC A03/MF A01