| Main Title |
Detection of mutagenic/carcinogenic alteration in fish {MICROFICHE} |
| Author |
Hinton, David E. ;
Klaunig, James E. ;
Lipsky, Michael M. ;
Jack, Rhona M. ;
Trump, Benjamin F.
|
| Other Authors |
|
| CORP Author |
Maryland Univ., Baltimore. School of Medicine.;Environmental Research Lab.-Duluth, MN. |
| Publisher |
U.S. Environmental Protection Agency, Environmental Research Laboratory ; |
| Year Published |
1983 |
| Report Number |
EPA-R-804866; EPA-600/3-83-076 |
| Stock Number |
PB83-253559 |
| Subjects |
Fishes--Diseases--United States ;
Mutagenicity testing ;
Carcinogenicity testing
|
| Additional Subjects |
Detection ;
Bioassay ;
Fishes ;
Indicator species ;
Levers ;
Mutagenesis ;
Carcinogenesis ;
Bioindicators ;
Water pollution detection
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-253559 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
114 p. : ill. ; 28 cm. |
| Abstract |
The feasibility of using fish as bioassay organisms to detect mutagenic/carcinogenic substances in the aquatic environment was tested. The data in fish were compared to those in higher vertebrates including humans. Microsomal fractions from livers of channel catfish, fathead minnow, bluegill sunfish, brown bullhead, rainbow trout, and mummichogs were studied to determine the presence and relative amounts/activities of microsomal protein, cytochromes P-450 and b5, NADPH cytochrome C reductase, aminopyrine demethylase, and aryl hydrocarbon hydroxylase. The effects, both morphologic (upon the endoplasmic reticulum) and biochemical, of exposure to known MFOS including agents, PCBs, benzo(a)pyrene, and 3-methylcholanthrene were studied. |
| Notes |
Distributed to depository libraries in microfiche. "Aug. 1983." "EPA-600/3-83-076." Microfiche. |
| Place Published |
Duluth, MN : |
| Corporate Au Added Ent |
Environmental Research Laboratory (Duluth, Minn.) |
| PUB Date Free Form |
1983. |
| NTIS Prices |
PC A06/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20011107134538 |
| Language |
eng |
| Origin |
NTIS |
| Type |
MERGE |
| OCLC Rec Leader |
01187nam 2200277Ka 45020 |
