||Carcinogenicity and pesticides : principles, issues, and relationships. Biological issues in extrapolation. /
Yang, Raymond S. H. ;
Huff, J. ;
Germolec, D. R. ;
Luster, M. I. ;
Simmons, J. E.
||Health Effects Research Lab., Research Triangle Park, NC. ;PATHCO, Inc., Research Triangle Park, NC. ;Department of Agriculture, Washington, DC. ;Maryland Univ., College Park.;American Chemical Society, Washington, DC.
|| U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Carcinogens, Environmental--toxicity ;
Neoplasms--chemically induced ;
Carcinogens, Environmental--toxicity--congresses ;
Neoplasms--chemically induced--congresses ;
Carcinogenicity tests ;
Risk assessment ;
Species specificity ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||25 pages : illustrations ; 28 cm.
||To assess potential risks of chemicals to humans, extrapolation of the findings in laboratory animals to possible health effects in humans is inevitable. Several important biological issues must be considered in such a process; these include extrapolation between doses, species (including strain and sex), routes of administration and exposure regimens (e.g., intermittent vs constant rate). While there is no perfect surrogate for humans in the evaluation of carcinogenic potential and other toxicities of chemicals and other agents, rodents still represent the best models. Any imperfection in such a process (i.e., hazard identification and risk assessment of any given chemical or other agent) must be taken into consideration during extrapolation.
||"Developed from a symposium sponsored by the Division of Agrochemicals at the 196th National Meeting of the American Chemical Society, Los Angeles, California, September 25-30, 1988." Includes bibliographical references. "Jane Ellen Simmons, project officer." Microfiche.
||Research Triangle Park, NC :
||Pub. in ACS (American Chemical Society) Symposium Series 414, Chapter 9, p142-163, 1 Nov 89. See also PB90-119215. Presented at Symposium on Division of Agrochemicals at the National Meeting of the American Chemical Society (196th), Los Angeles, California, September 25-30, 1988. Prepared in cooperation with PATHCO, Inc., Research Triangle Park, NC., Department of Agriculture, Washington, DC.,
|Corporate Au Added Ent
||United States. Environmental Protection Agency. Office of Research and Development. ; Health Effects Research Laboratory. ; American Chemical Society. Meeting
||Biological issues in extrapolation.
|PUB Date Free Form
|Series Title Traced
||ACS symposium series, 414
||PC A03/MF A01
|OCLC Time Stamp
|OCLC Rec Leader
||02038nam 2200421Ka 45020