Main Title |
Reproductive Toxicity of a Single Dose of 1,3-Dinitrobenzene in Two Ages of Young Adult Male Rats. |
Author |
Linder, R. E. ;
Strader, L. F. ;
Barbee, R. R. ;
Rehnberg, G. L. ;
Perreault, S. D. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/018; |
Stock Number |
PB90-217415 |
Additional Subjects |
Toxicity ;
Reproduction(Biology) ;
Rats ;
Males ;
Testis ;
Histology ;
Reprints ;
Dinitrobenzenes ;
Epididymis ;
Organ weight ;
Spermatozoa ;
Dose-response relationships
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-217415 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
17p |
Abstract |
The studies evaluated the reproductive response and the possible influence of testicular maturation on the reproductive parameters, in male rats treated with 1,3-Dinitrobenzene (M-DNB). Young adult male rats (75 or 105 days of age) were given a single oral dose of 0, 8, 16, 24, 32, or 48 mg/kg of m-DNB and killed at 14 days post-treatment. Mortality and neurotoxicity were observed at 48 mg/kg but only in the older animals. Epididymis weight, testicular sperm head counts, cauda sperm reserves, and sperm morphology were affected at 16 and 24 mg/kg and higher in the older and younger animals, respectively. Testis weight and sperm motility were affected at 24 mg/kg and higher in both age groups. Histologic changes included maturation depletion of mid and late spermatids at 16 mg/kg and higher, atrophy of a few to many seminiferous tubules at 24 mg/kg and higher, and immature germ cells in the epidymis. The movement and/or mixing of luminal elements in the epididymis appeared to be influenced by severe testicular effects. In separate groups given only the 48 mg/kg dosage, fertilizing ability was lost by 5-6 weeks post-treatment and several animals failed to recover in 5 months. (Copyright (c) 1990 Society of Toxicology.) |
Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v14 p284-298 1 Jan 90. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Reproductive Toxicity of a Single Dose of 1,3-Dinitrobenzene in Two Ages of Young Adult Male Rats. |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
019411094 |
Origin |
NTIS |
Type |
CAT |