| Main Title |
Genotoxic Properties of Haloacetonitriles: Drinking Water By-Products of Chlorine Disinfection. |
| Author |
Daniel, F. B. ;
Schenck, K. M. ;
Mattox, J. K. ;
Lin, E. L. C. ;
Haas, D. L. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/342; |
| Stock Number |
PB87-180782 |
| Additional Subjects |
Halogen organic compounds ;
Acetonitriles ;
Chlorination ;
Water treatment ;
Disinfection ;
Public health ;
Bioassay ;
Carcinogens ;
Hazards ;
Toxicity ;
Humans ;
Cells(Biology) ;
Exposure ;
Reprints ;
Drinking water ;
Water pollution effects(Humans)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-180782 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Chlorinated and brominated haloacetonitriles (HAN), known drinking water contaminants which form during chlorine disinfection, were investigated for genotoxic activity. The HAN produced DNA strand breaks in cultured human lymphoblastic (CCRF-CEM) cells, bound to the nucleophilic trapping agent 4-(p-nitrobenzyl) pyridine and formed a covalent bond to polyadenylic acid in a cell-free reaction system. Thus, the authors have demonstrated that these chemicals are genotoxic, which would indicate a potential for carcinogenic activity and for human health hazard. |
| Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v6 n3 p447-453 Apr 86. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Genotoxic Properties of Haloacetonitriles: Drinking Water By-Products of Chlorine Disinfection. |
| PUB Date Free Form |
1986 |
| Category Codes |
50B; 68D; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
720518703 |
| Origin |
NTIS |
| Type |
CAT |
