Main Title |
Intramembrane-Cleaving Proteases (I-CLiPs) [electronic resource] / |
Type |
EBOOK |
Author |
Hooper, Nigel M.
|
Other Authors |
|
Publisher |
Springer Netherlands, |
Year Published |
2007 |
Call Number |
RC321-580 |
ISBN |
9781402063114 |
Subjects |
Medicine ;
Neurosciences ;
Cytology
|
Internet Access |
|
Collation |
IX, 142 p. online resource. |
Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
Contents Notes |
The Site-2 Protease at Ten -- Signal Peptide Peptidases -- GXGD-Type Intramembrane Proteases -- Rhomboid Intramembrane Serine Proteases -- Proteases of the Rhomboid Family in the Yeast Saccharomyces Cerevisiae -- ?-Secretase And Alzheimer'S Disease -- ?-Secretase Mediated Proteolysis: At the Cutting Edge of Notch Signaling. In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called 'intramembrane-cleaving proteases' (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer's and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs. |
Place Published |
Dordrecht |
Corporate Au Added Ent |
SpringerLink (Online service) |
Title Ser Add Ent |
Proteases in Biology and Disease ; 6 |
Host Item Entry |
Springer eBooks |
PUB Date Free Form |
2007 |
Series Title Untraced |
Proteases in Biology and Disease ; 6 |
BIB Level |
m |
Medium |
computer |
Content |
text |
Carrier |
online resource |
Cataloging Source |
OCLC/T |
OCLC Time Stamp |
20140824033852 |
Language |
eng |
Origin |
SPRINGER |
Type |
EBOOK |
OCLC Rec Leader |
02919nam a22004575i 45 |