||Pulmonary Clearance of Inhaled Particles 24 to 48 Hours Post Deposition: Effect of Beta-Adrenergic Stimulation.
Bennett, W. D. ;
Chapman, W. F. ;
Lay, J. C. ;
Gerrity, T. R. ;
||North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology.;Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch.
||c10 Jul 91
Beta adrenergic receptors ;
Air pollutants ;
Airway resistance ;
Organotechnetium compounds ;
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||Recent studies have suggested considerable particle retention in the bronchial ciliated airways 24 hours after depositing in the lung. A significant presence of particles in the ciliated airways at 24 hours post deposition may be indicated if beta-adrenergic treatment between 24 and 48 hours is shown to enhance particle clearance during this same period. The hypothesis was tested in ten young, normal subjects who inhaled Tc99m-iron oxide particles (5 micrometers MMAD) on three separate occasions. Following the first aerosol exposure, each subject inhaled a dose of albuterol sufficient to decrease specific airway resistance by 63% and clearance was measured by gamma camera over a 3 hour period. For the subsequent two aerosol exposures, baseline mucociliary clearance was measured, again over the initial 3 hour period, and then retention of particles was monitored with a six crystal gamma detector between 24 and 48 hours. During this 24-48 hour period, each subject inhaled 2 doses of either albuterol (a similar dose to that described above) or saline (double-blinded design). Albuterol significantly enhanced clearance at one hour post deposition.
||Pub. in Jnl. of Aerosol Medicine, v6 n1 p53-62 Mar 93. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch.
|NTIS Title Notes
||Reprint: Pulmonary Clearance of Inhaled Particles 24 to 48 Hours Post Deposition: Effect of Beta-Adrenergic Stimulation.
||PC A02/MF A01