| Main Title |
Central and Sympatho-Adrenal Responses to Insulin in Adult and Neonatal Rats (Journal Version). |
| Author |
Lau, C. ;
Bartolome, J. V. ;
Bartolome, M. B. ;
Slotkin, T. A. ;
|
| CORP Author |
Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1987 |
| Year Published |
1987 |
| Report Number |
EPA-68-02-4450 ;EPA-68-02-4032; EPA/600/J-87/412; |
| Stock Number |
PB89-105589 |
| Additional Subjects |
Insulin ;
Catecholamines ;
Adrenal glands ;
Central nervous system ;
Hypoglycemia ;
Laboratory animals ;
Secretion ;
Newborn animals ;
Sympathetic nervous system ;
Ornithine decarboxylase ;
Aging ;
Insulin receptors ;
Reprints ;
Sympatho-adrenal development
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105589 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
In the mature rat, subcutaneous administration of insulin (0.02 IU/g body wt.) produced hypoglycemia and a profound activation of the sympatho-adrenal pathway, as indicated by a marked depletion of adrenal catecholamines. Cellular glucopenia caused by administration of 2-deoxyglucose also produced a sympatho-adrenal response. In contrast, in 2-day-old rats, the systemic injection of insulin evoked only a small depletion of catecholamines even though severe hypoglycemia was present, and 2-deoxyglucose also produced a diminished response. The central administration of insulin at an equivalent dose (0.02 IU/g brain) stimulated brain ornithine decarboxylase activity in both neonates and adults, but was ineffective in evoking hypoglycemia or adrenal catecholamine release. These results suggest that: (a) direct interaction of insulin with its receptors in the central nervous system is not required for activation of the sympatho-adrenal pathway, and (b) the lack of sensitivity of neonatal adrenal catecholamine release to subcutaneous administration of insulin is likely associated with immaturity of splanchnic neurotransmission rather than with absence of central insulin receptors or impaired peripheral responsiveness to insulin. (Copyright (c) Elsevier Science Publishers B.V.) |
| Supplementary Notes |
Pub. in Developmental Brain Research, v36 p277-280 1987. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Central and Sympatho-Adrenal Responses to Insulin in Adult and Neonatal Rats (Journal Version). |
| Category Codes |
57F; 57B; 57Q |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
834421744 |
| Origin |
NTIS |
| Type |
CAT |
